先前研究表明产前宠物暴露和免疫球蛋白E（IGE）轨迹之间的关联通过年龄段。确定此协会在10-14岁时是否持续存在，研究人员评估了对密歇根州东南部的1,193母婴对的队列数据。该研究小组发现，与没有这种暴露的人相比，10-14岁10-14岁的IgE水平曲线下的曲线下降28.8％。狗所有权，与射灯的26.7％有关，是本协会的主要驱动因素，猫所有权与IgE轨迹无明显关联。调查结果支持“卫生假设”，Jay Portnoy，MD-谁没有参与该研究，在一份声明中 - 这是基于狗是来自外面的细菌的特定载体并导致潜在的影响child’s microbiome early in develop. The hypothesis is supported by previous studies suggesting an association between dog ownership and reduced risk of eczema in children. Race/Ethnicity and delivery method affected the association between pet exposure and IgE reductions, with children of African-American mothers experiencing an 11.3% reduction versus a 33.6% reduction in other races and ethnicities, and children delivered via cesarean delivery experiencing a 46.2% lower IgE trajectory versus an 18.1% lower trajectory in children delivered vaginally.